What is Adsense optimized layout? First of all, content area must be
728px width (for 728*90 banner). Sidebar must be
300px width (for 300*250 banner). Also padding in content must be small and layout must have block and compact view.
From 5.3.2 version of theme you can make layout Adsense oriented with option in Theme options Affiliate Enable adsense optimized layout for desktop .
Please, use this option only if you have Adsense as main money income source on your site.